Welcome!

We are a research team at the University of Zürich studying the impact of a fascinating male meiotic driver called t haplotype on populations of wild house mice.

The t haplotype is a naturally occurring variant of mouse chromosome 17 that evades Mendel’s rules of inheritance. It manipulates sperm development in male carriers such that it is transmitted to 90% of offspring instead of the 50% expected by Mendelian inheritance. This transmission advantage, known as ‘meiotic drive’, allows the t haplotype to persist or even propagate in populations despite severe fitness cost to its carriers (some t versions are lethal, others cause male sterility). In our lab, we investigate the behavioural, evolutionary, and ecological impact of the t haplotype on wild house mouse populations. Find out more ➤